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Picralima nitida is a plant that is grown in tropical climates. As with Mitragyna speciosa, the kratom plant, it is often harvested in the wilds. The Akuamma seeds contain two potent alkaloids: akuammine and pericine. Akuammine is structurally in sync with mitragynine, the most effective alkaloid in kratom.

The main alkaloids making the plant highly potent and effective include;

  • Akuammidine- this is the seeds’ main alkaloid and works by influencing opioid binding sites. The alkaloid provides analgesic qualities to help in eradicating pain as well as serving as a muscle relaxant.
  • Akuammine- this alkaloid has a higher affinity for mu-opioid binding sites, unlike the Akuammidine. It helps with providing analgesic effects, however, may cause an inhibitory impact on the peristaltic movement of the intestines if used in higher doses.
  • Akuammicine- this alkaloid, on the other hand, has a higher affinity for kappa-opioid binding sites.
  • Pseudo-Akuammigine- this alkaloid provides both anti-inflammatory and analgesic effects. Depending on the dosage, the alkaloid excites, modulates the skeletal muscle contraction, smooth muscle contraction, central nervous system, and respiration.
  • Akuammigine- this one has only shown to have an anti-adrenergic effect on blood vessels as well as the heart.
  • Pericine- this one has been indicated to bind to mu-opioid receptors, however, may cause convulsions resulting in involuntary contraction of muscles.

Akuamma is known to induce a sense of well-being. In certain doses, Akuamma may also make for a restful experience. It is extremely similar to kratom in this regard.


The alkaloids extracted from akuamma have been indicated to have opioid analgesic activity. Over time, individuals have turned to use akuamma seed to get rid of the pain caused by such conditions as migraines, fibromyalgia, and arthritis among others effectively.

It is even regarded as a better alternative to opiates that come with withdrawal side effects and addiction. The seeds from this plant are purely natural and have very few side effects. You may as well take the seeds for sore muscles to get immediate pain relief after roughly 15-30 minutes.


Alkaloid extracts from akuamma have been investigated for anti-inflammatory activity and results indicated that pseudo-Akuammigine significantly reduced the mean maximal and total swelling after oral administration of the alkaloid.

Antioxidant and Anti-Diabetic Activities

Diabetes Mellitus is a common metabolic condition usually associated with oxidative stress and characterized by chronic hyperglycemia.

According to medical studies investigating the antioxidant and ant-diabetic potential of methanol extracts of the leaves and stems of akuamma plant, it was observed that the methanol leaf extract of the herb exhibited remarkable hypoglycemia activity with roughly 38% of glycemia reduction thanks to the alkaloid-akuammicine, which is believed to promote glucose uptake of the cells, thus reducing the level of glucose in the bloodstream.

From these findings, it is evident that akuamma plant has both antioxidant and anti-diabetic properties hence can be used to effectively treat diabetes mellitus as well as serve as the basis upon which new and powerful drugs can be developed to help in the treatment of diabetes and related health conditions.

Sedative Activity

The seed extracts of this herb are known to minimize stress and anxiety to give one a calming, soothing, and generally relaxing effect. It has also been indicated to help counter panic attacks whereas it is also considered for sedation purposes by people who experience sleep problems like insomnia and nightmares.

The seeds have strong sedative properties hence guarantee the most peaceful sleep if taken just before bedtime. It is also reported that the calming effects of the herb will be experienced almost immediately allowing you to enjoy a good rest free of pain, stress or anxiety.

For educational purposes only. This information has not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.
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